Professor C Louise Thwaites
Contact information
Websites
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VITAL project
The VITAL project aims to reduce morbidity and mortality from infectious diseases in Asia by using innovative technology and clinical approaches
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PHENOM-AI
PHENOM-AI aims to develop AI-powered tools, wearables, and immune profiling techniques to improve pneumonia diagnosis and treatment in resource-limited intensive care settings worldwide for ill patients.
Colleges
C Louise Thwaites
BSc MBBS MRCP MD DMSMed MLCOM
Professor of Experimental Critical Care
- Senior Clinical Research Fellow
Emerging Infection
Professor Louise Thwaites is a clinical researcher and expert in critical care and emerging infections, with appointments at the Centre for Tropical Medicine and Global Health, University of Oxford, and the Oxford University Clinical Research Unit (OUCRU) in Ho Chi Minh City, Vietnam. She holds a Research Fellowship at Linacre College.
Her work focuses on improving outcomes for critically ill patients in resource-limited settings. She has longstanding research interests in severe infectious diseases, including tetanus, sepsis, dengue and pneumonia, and has led major clinical trials, including studies of magnesium sulphate and intrathecal antitoxin in tetanus.
Her research programme aims to advance the diagnosis and management of severe infections through innovative technologies adapted for low-resource environments. This includes the application of wearable physiological monitoring and artificial intelligence–based risk prediction in the VITAL project. She currently leads PHENOM-AI, a multidisciplinary UK–Vietnam collaboration integrating artificial intelligence, advanced pathogen identification and immune profiling to better characterise pneumonia and inform future diagnostic and treatment strategies.
Professor Thwaites is a board member of the BMJ Future Health initiative, and plays an active role in international guideline and policy development. She is a member of the Asia Pacific Sepsis Association and contributes to the Sepsis in Resource-Limited Settings Consensus Group of the European Society of Intensive Care Medicine. She serves as an expert consultant to the World Health Organization (WHO), is a member of the WHO advisory group for COVID-19 Clinical Management Living Guidelines, the WHO Global Clinical Platform Technical Advisory Group, and the WHO O2ptimising Respiratory Care Working Group. She is also a board member of the BMJ Future Health initiative.
Key publications
Tetraspanin-based immunocapture for high-depth proteomic profiling of extracellular vesicles from cerebrospinal fluid for biomarker discovery
Journal article
Dellar ER. et al, (2026), Clinical Proteomics, 23
Perceptions of death, dying and the body in Vietnamese culture: A qualitative exploration from a study examining the potentials of minimally invasive tissue sampling in Vietnam
Journal article
Doan NP. et al, (2026), SSM - Qualitative Research in Health, 9, 100714 - 100714
Ensuring vaccine cold chain integrity: A rapid and low-cost test for identifying heat-exposed sucrose-containing vaccines
Journal article
Arman BY. et al, (2026), International Journal of Pharmaceutics: X, 11, 100467 - 100467
Advancing the concept of community positive health through participatory research in marginalized communities in Kenya
Journal article
Peters LER. et al, (2026), Social Science & Medicine, 398, 119147 - 119147
Rickettsial seropositivity in Lao PDR smallholder livestock farms: Implications for animal and human health.
Journal article
Tawfik C. et al, (2026), One health (Amsterdam, Netherlands), 22
Deformation-Recovery diffusion model (DRDM): Instance deformation for image manipulation and synthesis
Journal article
Zheng J-Q. et al, (2026), Medical Image Analysis, 110, 103987 - 103987
The normalisation of under-resourcing limits the potential for improvement of critical care: evidence from a multi-method study of Kenyan hospitals
Journal article
McKnight J. et al, (2026), Social Science & Medicine, 396, 118843 - 118843
Trends in pneumothorax mortality in England (2004–2023): a population-based observational study
Journal article
Zhong X. et al, (2026), The Lancet Regional Health - Europe, 64, 101632 - 101632
Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer
Journal article
Mulholland-Illingworth EJ. et al, (2026), Iscience, 29
Characterisation of bacteria‐induced colitis and its modulation by probiotics in naked mole rats: a new mammalian model for acute inflammatory disease
Journal article
Hart DW. et al, (2026), The Journal of Pathology, 268, 493 - 511
Vibrotactile positional therapy for the treatment of positional obstructive sleep apnoea: a multicentre, randomised controlled trial
Journal article
Kelly JL. et al, (2026), Thorax, 81, 370 - 379
The ‘Public’ in Public Involvement: A Call to Centre Frontline Staff Voices in Health Workforce Research
Journal article
Zhao Y. et al, (2026), Health Expectations, 29
Prospects and perils of antimicrobial resistance cluster detection using routinely collected data: an illustration from tertiary hospitals in Thailand representing different data contexts
Journal article
Rangsiwutisak C. et al, (2026), Journal of Hospital Infection, 170, 48 - 59
Voices from the frontline: how global funding cuts are reshaping the viral hepatitis response
Journal article
Delphin M. et al, (2026), The Lancet Gastroenterology & Hepatology, 11, 269 - 271
Core outcome measurement set for clinical trials in dengue: an international Delphi consensus study (DEN-CORE)
Journal article
Yacoub S. et al, (2026), The Lancet Infectious Diseases, 26, e231 - e244
Toward Integration of Molecular Measures and Artificial Intelligence-Based Assessments With Clinical End Points in Inflammatory Bowel Disease
Journal article
Reinisch W. et al, (2026), Gastroenterology, 170, 686 - 703
Acute upper gastrointestinal bleeding in the UK: 2022 audit update
Journal article
Nigam GB. et al, (2026), Gut, 75, 760 - 771
Age distribution of respiratory syncytial virus disease in children younger than 5 years in low-income and middle-income countries: a systematic review and meta-analysis
Journal article
Mahmud S. et al, (2026), The Lancet Child & Adolescent Health, 10, 245 - 254
Women with chronic pelvic pain can be stratified using multimodal assessment.
Journal article
Demetriou L. et al, (2026), Pain, 167, 786 - 802
Cohort Profile: the SMRU Refugee and Migrant Pregnancy Study in Western Thailand and Eastern Myanmar
Journal article
McGready R. et al, (2026), Wellcome Open Research, 11, 21 - 21
Evaluating the biomedical and behavioral drivers of HIV incidence decline in adolescent girls and young women in Uganda: A mathematical modeling study.
Journal article
Akullian A. et al, (2026), PLoS Med, 23
Refined USP25/28 inhibitors with improved selectivity towards c-Myc driven squamous lung cancer cells
Preprint
Pinto-Fernández A. et al, (2026)
Rational Design of a Chimpanzee Adenoviral-Vector Vaccine Against Yellow Fever Through the Modification of Antigen Transmembrane Domains
Journal article
Ulaszewska M. et al, (2026), Vaccines, 14, 273 - 273
Skin cancer in transplant recipients: time to revisit immunosuppression trials?
Journal article
Bottomley MJ., (2026), British Journal of Dermatology, 194, 619 - 620
Chronic Malaria Is Associated With Trauma-related Splenic Rupture Requiring Splenectomy
Journal article
Shanti PAI. et al, (2026), The Journal of Infectious Diseases, 233, e740 - e744
Assessing the innovation competency and entrepreneurial capacity of health students in Vietnam: a cross-sectional study
Journal article
Le ANT. et al, (2026), BMC Medical Education
Impact of switching from manual to automated aerobic blood culture on bacteremia diagnosis in Lao PDR
Journal article
Jaksuwan R. et al, (2026), Microbiology Spectrum
Identification of transporters essential for survival of Leishmania promastigotes in the digestive tract of sand flies
Journal article
Sádlová J. et al, (2026), PLOS Pathogens, 22, e1014049 - e1014049
Development and Evaluation of Compact Semi-Synthetic Promoters for Enhanced Antigen Expression in Adenoviral-Vectored Vaccines
Journal article
Hlaváč M. et al, (2026), Vaccines, 14, 260 - 260
Dopamine release from Parkinson's patient-derived neurons is disrupted due to impaired synaptic vesicle loading
Preprint
Cramb KML. et al, (2026)
Chromosomal instability shapes the tumor microenvironment of esophageal adenocarcinoma via a cGAS–chemokine–myeloid axis
Journal article
Beernaert B. et al, (2026), Science Advances, 12
Research without borders: advancing equitable global partnerships to accelerate HBV elimination efforts
Journal article
Batbold E. et al, (2026), Nature Reviews Gastroenterology & Hepatology
Biosafety and biosecurity for Burkholderia pseudomallei and Burkholderia mallei : evidence, gaps, and sustainable practice in endemic, low-resource settings
Journal article
Blacksell SD. et al, (2026), Clinical Microbiology Reviews
Using peptide-exchange systems to interrogate peptide-specific KIR binding to HLA Class I
Preprint
Murali TM. et al, (2026)
Ubiquitin E3 ligase KLHL6 brings exhausted T-cells back into action
Journal article
Chen Z. et al, (2026), Immunity & Inflammation, 2
Estimating the changing prevalence of molecular markers of artemisinin partial resistance in Plasmodium falciparum malaria in Sub-Saharan Africa
Preprint
Harrison LE. et al, (2026)
Determinants of mortality following snakebite envenomation: a matched case–control study in northeastern Nigeria
Journal article
Hamman NA. et al, (2026), Transactions of The Royal Society of Tropical Medicine and Hygiene, 120, 277 - 289
Determinants of mortality following snakebite envenomation: a matched case–control study in northeastern Nigeria
Journal article
Hamman NA. et al, (2026), Transactions of The Royal Society of Tropical Medicine and Hygiene, 120, 277 - 289
Parasitological efficacy of seasonal malaria chemoprevention in Nampula, northern Mozambique
Journal article
Bonnington C. et al, (2026), Transactions of The Royal Society of Tropical Medicine and Hygiene, 120, 258 - 267
Longitudinal Epidemiology and Variant Dynamics of SARS-CoV-2 in Coastal Kenya (2020–2025): Clinical Features and Wave Patterns
Journal article
Lambisia AW. et al, (2026), Open Forum Infectious Diseases, 13
ESR1 Mutation in Endocrine Treatment-Naïve Endometrial Cancer: Prevalence, Characteristics, and Prognostic Implications, Results from the UTOLA Phase II GINECO Trial
Journal article
Blanc-Durand F. et al, (2026), Clinical Cancer Research, 32, 963 - 969
The Role of Fibroblast–Epithelial Cross-Talk on the Distribution of Distinct Fibroblast Phenotypes in the Intestinal Crypt
Journal article
Atkinson G. et al, (2026), Bulletin of Mathematical Biology, 88
Population pharmacokinetics of lumefantrine in pregnant and non‐pregnant women with uncomplicated Plasmodium falciparum malaria in Western Kenya
Journal article
Juma E. et al, (2026), British Journal of Clinical Pharmacology, 92, 911 - 921
Urinary carbonic anhydrase 1 excretion is a marker of hemolysis-triggering conditions suitable for point-of-care testing
Journal article
Hulikova A. et al, (2026), Blood Global Hematology, 2, 100058 - 100058
Impact of an electronic clinical decision support algorithm (eCDSA) on antibiotic prescribing in primary care in Cambodia: A cluster randomised controlled trial
Journal article
Wynberg E. et al, (2026), International Journal of Infectious Diseases, 164, 108382 - 108382
Data reuse in global health: perspectives from actors in policy, funding and research
Journal article
Waithira N. et al, (2026), BMJ Global Health, 11, e021974 - e021974
Genotype-stratified adjunctive dexamethasone for tuberculous meningitis in HIV-negative adults: a randomized controlled phase 3 trial
Journal article
Donovan J. et al, (2026), Nature Medicine, 32, 849 - 858
Protocol for stable cell line production to express muscle-type nicotinic receptor
Journal article
Li A. et al, (2026), STAR Protocols, 7, 104427 - 104427
The potential of a centrally implemented system for national surveillance of bloodstream infections in England, compared to current local surveillance, 2023–2024
Journal article
Cregan J. et al, (2026), Journal of Hospital Infection, 169, 5 - 14
Addressing pandemic-wide systematic errors in the SARS-CoV-2 phylogeny
Journal article
Hunt M. et al, (2026), Nature Methods, 23, 653 - 662
Intratumoral heterogeneity and immunotherapy resistance: clinical implications
Journal article
Keenan BP. et al, (2026), Annals of Oncology, 37, 314 - 328
British Society of Gastroenterology guidelines on colorectal surveillance in inflammatory bowel disease
Journal article
East JE. et al, (2026), Gut, 75, 442 - 475
HepB-boost: Implementation of free-of-charge health care worker hepatitis B testing and vaccination at Kilifi County Referral Hospital, Kenya
Journal article
Downs LO. et al, (2026), International Journal of Infectious Diseases, 164, 108418 - 108418
Risk Factors of Metabolic Dysfunction-associated Steatotic Liver Disease in a Cohort of Patients With Chronic Hepatitis B
Journal article
Kalafateli M. et al, (2026), Clinical Gastroenterology and Hepatology, 24, 701 - 712.e8
Vaccine effectiveness of a bivalent respiratory syncytial virus (RSV) pre-F vaccine against RSV-associated hospital admission among adults aged 75–79 years in England: a multicentre, test-negative, case–control study
Journal article
Symes R. et al, (2026), The Lancet Infectious Diseases, 26, 229 - 238
Recent publications
Foundation models enable wearable signal screening for cardiovascular disease among people living with HIV
Journal article
Mesinovic M. et al, (2026), Communications Medicine, 6
Acute breathlessness in resource-limited settings: diagnostic gaps and treatment challenges.
Journal article
Le Hong V. and Thwaites CL., (2025), Thorax
Molnupiravir or nirmatrelvir–ritonavir plus usual care versus usual care alone in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
Journal article
Abani O. et al, (2025), The Lancet Infectious Diseases, 25, 1000 - 1010
High immunisation coverage but sporadic outbreaks of vaccine-preventable diseases: the structural gaps in vaccination uptake in central highlands, Vietnam.
Journal article
Nguyen TH. et al, (2025), BMC public health, 25