Matthias Friedrich
Dr. rer. biol. hum.
Group Leader (Wellcome Trust Career Development Award)
Gastrointestinal Pathophysiology - Translational and Experimental Research
Research
My team is interested in the cellular and molecular mechanisms of chronic inflammation and fibrosis. Whilst the focus is on Inflammatory Bowel Diseases (IBDs), we aim to identify shared and distinct patho-mechanisms across organs. Combining cutting edge digital pathology and AI approaches, spatial/single-cell/bulk genomics and proteomics, highly multiplexed immunohistochemistry and flow cytometry, we profile large patient cohorts. This is complemented by mechanistic studies of in vivo disease models and in vitro organotypic cell cultures. Current projects strive to personalise medical therapy in IBD, finding alternative treatments for fibrotic Crohn's disease, and establishing a molecular basis for symptoms in ulcerative colitis.
Team
Research Assistants:
Osheen Sharma
Postdocs:
Hosuk Ryou
Bin Li (co-supervision)
DPhil (co-supervision):
Zhi Wong
Clinical DPhils (co-supervision):
Rahul Ravindran
Julia Pakpoor
Tom Hosack
Students:
Kaiyang Song
Recent publications
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MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses
Journal article
Heuberger CE. et al, (2023), Mucosal Immunology
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Adipocyte autophagy limits gut inflammation by controlling oxylipin and IL‐10
Journal article
Richter FC. et al, (2023), The EMBO Journal, 42
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MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T cell responses
Preprint
Heuberger CE. et al, (2023)
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Systemic and T cell-associated responses to SARS-CoV-2 immunisation in gut inflammation (STAR SIGN study): effects of biologics on vaccination efficacy of the third dose of mRNA vaccines against SARS-CoV-2.
Journal article
Woelfel S. et al, (2023), Alimentary pharmacology & therapeutics, 57, 103 - 116
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Hermansky-Pudlak syndrome type 1 causes impaired anti-microbial immunity and inflammation due to dysregulated immunometabolism
Journal article
Cavounidis A. et al, (2022), Mucosal Immunology, 15, 1431 - 1446