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Matthias Friedrich

Dr. rer. biol. hum.

Group Leader (Wellcome Trust Career Development Award)

Gastrointestinal Pathophysiology - Translational and Experimental Research


My team is interested in the cellular and molecular mechanisms of chronic inflammation and fibrosis. Whilst the focus is on Inflammatory Bowel Diseases (IBDs), we aim to identify shared and distinct patho-mechanisms across organs. Combining cutting edge digital pathology and AI approaches, spatial/single-cell/bulk genomics and proteomics, highly multiplexed immunohistochemistry and flow cytometry, we profile large patient cohorts. This is complemented by mechanistic studies of in vivo disease models and in vitro organotypic cell cultures. Current projects strive to personalise medical therapy in IBD, finding alternative treatments for fibrotic Crohn's disease, and establishing a molecular basis for symptoms in ulcerative colitis.   


Research Assistants:

Osheen Sharma


Hosuk Ryou 

Bin Li (co-supervision)

DPhil (co-supervision):

Zhi Wong

Clinical DPhils (co-supervision):

Rahul Ravindran

Julia Pakpoor

Tom Hosack


Kaiyang Song