Contact information
Receptor Inhibition by Phosphatase Recruitment
Research groups
Ricardo A. Fernandes
CAMS Oxford Institute Group Leader
Cancer Immunology - T cell signalling
The main objective of our research group is to identify key functional aspects affecting anti-tumor responses by T cells. To do this, we use protein engineering, guided by structural and signaling information, to generate novel molecules that allow us to explore and interrogate key aspects of receptor signaling and T cell function. We are currently focusing our efforts in developing molecules to overcome “inhibitory” signaling by immune checkpoint receptors and to enhance signaling by the T-cell receptor.
Ricardo Fernandes recently joined CAMS Oxford Institute coming from Stanford where he developed novel molecules to effectively shut down signaling by immune receptors such as PD-1.
Recent publications
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SARS-CoV-2 transmission in opposition-controlled Northwest Syria: modelling pandemic responses during political conflict
Journal article
Marzouk M. et al, (2022), International Journal of Infectious Diseases
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Estimating the programmatic cost of targeted mass drug administration for malaria in Myanmar
Journal article
Kyaw SS. et al, (2021), BMC Public Health, 21
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Algorithm in the Diagnosis of Febrile Illness Using Pathogen-specific Rapid Diagnostic Tests.
Journal article
Pokharel S. et al, (2020), Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 70, 2262 - 2269
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Determinants of MDA impact and designing MDAs towards malaria elimination
Journal article
Gao B. et al, (2020), eLife, 9
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High turnover drives prolonged persistence of influenza in managed pig herds
Journal article
Pitzer VE. et al, (2016), Journal of The Royal Society Interface, 13, 20160138 - 20160138