Nuffield Professor of Clinical Medicine and Head of Department
- Professor of Immunology
- MRC Investigator
Our aim is to understand how the immune system is formed and regulated and the causes of autoimmunity, particularly the systemic autoimmune diseases, and the development and selection of B cells. Adverse immunological reactions to self and foreign antigens that lead to autoimmune or inflammatory disease place a major economic and social burden on world health and individual quality of life. We are also interested in how people differ in their inherited susceptibility to these diseases and why these differences are sustained in human populations by natural selection. Advances in this area will have a large and impact on the management of human disease.
Our strategy involves research programmes in basic biology and in clinical medicine. In the first, we use transgenic models to investigate how lymphocytes function in health and in human disease and how our genes encode susceptibility to autoimmunity and immunodeficiency. In the second, which is a collaboration with Professor Simon Davis, we are developing ways to change the function of lymphocytes, turning them on in cancer and off during inflammation or autoimmunity.
Tissue-resident memory T cells in pancreatic ductal adenocarcinoma co-express PD-1 and TIGIT and functional inhibition is reversible by dual antibody blockade.
Pearce H. et al, (2023), Cancer Immunol Res
Prolidase Deficiency Causes Spontaneous T Cell Activation and Lupus-Like Autoimmunity.
Hodgson R. et al, (2023), J Immunol
NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance.
Hodgson R. et al, (2022), Communications biology, 5
Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison
Ainsworth M. et al, (2020), The Lancet Infectious Diseases, 20, 1390 - 1400
Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19
Peng Y. et al, (2020), Nature Immunology, 21, 1336 - 1345