Roman Fischer
Associate Professor and Head of Discovery Proteomics Facility
In the Discovery Proteomics Facility of the Target Discovery Institute we provide advice in experimental design, sample preparation, sample analysis with state-of-the-art LCMS workflows and data analysis to researchers from Oxford University and national and international collaborators. We routinely use label-free quantitation, SILAC, TMT, SWATH and other methodologies on diverse samples (i.e. cells, tissues, immuno precipitates et al.) and have developed sample preparation techniques to access the deep proteome form little sample amounts using instrumentation such as Orbitrap Fusion Lumos or TimsTOF Pro.
My own interests evolve around clinical proteomics and applications for the spatial characterisation of the proteome in biological structures such as tissues and tumours. In addition, I am developing methodologies for the proteome characterisation of clinical cohort samples at high-throughput.
Recent publications
-
TEX264 drives selective autophagy of DNA lesions to promote DNA repair and cell survival.
Journal article
Lascaux P. et al, (2024), Cell, 187, 5698 - 5718.e26
-
Data from GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
Other
Wang Z. et al, (2024)
-
Supplementary Data from GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
Other
Wang Z. et al, (2024)
-
Supplementary Data from GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
Other
Wang Z. et al, (2024)
-
Supplementary Figures from GTP cyclohydrolase drives breast cancer development and promotes EMT in an enzyme-independent manner
Other
Wang Z. et al, (2024)