Professor Sophie Yacoub
Contact information
Podcast interview
Dengue research in Vietnam

Dengue is a global health concern exacerbated by urbanisation and climate change. OUCRU research themes include improving patient monitoring with wearable devices and clinical decision support systems, conducting clinical trials for therapeutics, assessing climate change's impact, and studying immune responses in high-risk groups. Our goal is to enhance early prediction and treatment strategies to improve patient care and health system efficiency.
Research groups
Sophie Yacoub
Associate Professor
- Lead for dengue research
Sophie is the Dengue Research Theme lead at the Pandemic Sciences Institute, University of Oxford. She’s a Physician in Infectious Diseases and General Medicine and holds an honorary Consultant appointment at London North West University Healthcare NHS Trust. She holds a PhD from Imperial and an MSc form the London School of Hygiene and Tropical Medicine.
She is a member of the Royal College of Physicians in London. Sophie led the dengue research group at the Oxford University Clinical Research Unit (OUCRU-Vietnam) from 2017-2025 where she set up a large translational programme of dengue research, focusing on clinical trials, pathogenesis studies and innovative technology centered on wearable devices, physiological monitoring and utilizing AI for medical imaging and clinical decision support systems.
She is now leading a global platform trial across 10 countries to investigate multiple therapeutics for patients hospitalised with dengue (DEN-Host Trial).
Recent publications
Persistent Subclinical Inflammation and Long-term Functional and Cognitive Outcomes After Dengue Shock and Septic Shock in Vietnam
Journal article
McBride A. et al, (2025), Open Forum Infectious Diseases, 12
The cost of dengue shock and septic shock in Vietnam: a patient-centred economic analysis
Journal article
McBride A. et al, (2025), International Health
Safety and tolerability of metformin in overweight and obese patients with dengue: An open-label clinical trial (MeDO)
Journal article
Minh Nguyen N. et al, (2025), PLOS Neglected Tropical Diseases, 19, e0013281 - e0013281
The influence of fluid resuscitation strategy on outcomes from dengue shock syndrome: a review of the management of 691 children in 7 Southeast Asian hospitals.
Journal article
Trieu HT. et al, (2025), BMJ global health, 10
Status of Digital Health Technology Adoption in 5 Vietnamese Hospitals: Cross-Sectional Assessment
Journal article
Tran DM. et al, (2025), JMIR Formative Research, 9, e53483 - e53483