Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Accept all cookies Reject all non-essential cookies Find out more

Tao Dong

Co-Director CAMS Oxford Institute

  • Ita Askonas Professor of Translational Immunology
  • Founding Director (Oxford), CAMS-Oxford joint International Centre for Translational Immunology
  • Founding Director (Oxford), Chinese Academy of Medical Sciences Oxford Institute (COI)

Biography

Tao Dong is the founding director of the CAMS-Oxford Institute based in Nuffield Department of Medicine, Oxford University since 2019. She has held the post of Professor of Immunology in the MRC Human Immunology Unit at Oxford University since 2014 and is a Senior Fellow at University College Oxford. In May 2023, Tao was appointed the Ita Askonas Professorship of Translational Immunology. 

Tao moved to Oxford University in 1993 where she received a DPhil degree in Immunology in 1998. In 2010 she became the Head of the human anti-viral and anti-cancer cytotoxic T cell laboratory and subsequently Program Leader in the MRC Human Immunology Unit at Oxford University. She has served as a panel member in varies international funding organisations, and SAB members for several pharmaceutical companies. 

Research Interests

The aim of Tao Dong’s research group is to investigate the functional aspects of antigen specific cytotoxic T cells (CTL) with a focus on the factors affecting CTL in controlling virus infection and cancer progression. While a robust and appropriate T cell response is typically beneficial to the host during human infections, a weak or inappropriate response can be ineffective or even have a detrimental effect. Over the past two decades, they have been working to understand the key factors required for efficient viral control by T cells in a number of different viral infections and cancer. Establishing both ex-vivo and in-vitro T cell functional evaluation platforms for antigen-specific T cells isolated from tissue and blood. By linking functional data with multi-omic single cell and T cell receptor (TCR) repertoire analysis, they continue to identify potential targets and pathways to augment and control the immune response as a way of improving the outcome of several important human diseases including SARS-CoV-2 virus infection and cancer.

Understanding the role of T cells in cancer

Our group are working to characterise and understand the T cell repertoire present in multiple sites that are influenced by cancer. By comparing T cells from different locations we can identify location-specific differences and potentially identify novel populations of T cells that are specific to a particular cancer. Once these T cells have been identified, we can assess their specificity by looking at their T cell receptor (TCR) sequences. Finally, we can investigate mechanisms of action and link phenotypic data to function, potentially opening avenues for therapeutic intervention in the future.  

Understanding the role of T cells in emerging viral infections

3WebsiteVirusCartoon1.png

For many years, our lab has been able to identify and characterise virus-specific T cells. During the pandemic we were able to streamline this process and create a pipeline for analysis of virus-specific T cells throughout the course of infection. Starting with identification of viral antigens through peptide screens, we can then identify key responses or factors that are associated with disease; establishing those that are protective from those that are pathogenic. With our platform we are able to evaluate how the long-term memory response is altered over time, as well as following re-infection or exposure to vaccines. Finally, we can rapidly assess how viral variants affect T cell responses. Altogether this allows us to get a good understanding of T cell responses in emerging viral infections and provides key research for future vaccines.