Tao Dong
Contact information
Louise Fraser
louise.fraser@ndm.ox.ac.uk
Weatherall Institute of Molecular Medicine
Colleges
Tao Dong
Founding Director (Oxford), Professor of Immunology
Human T cell response against virus and Cancer
The main objective of my group’s research is to focus on the functional aspects of the antigen specific T cells and studying the factors affecting T cells in controlling virus infection and cancer development.
For important human infections, cancer development and the course of disease is influenced mainly by the T cell response - while a robust and appropriate T cell response is beneficial to the host, a weak or inappropriate response can be ineffective or even have a detrimental effect. Numerous factors influence the quality of the T cell response to viral infections, predominant among them being the microenvironment of the infection site, the type of cells infected and the variability of the virus. By understanding the key factors required for efficient viral control by the T cell response in a number of different viral infections and viral associated cancer, we aim to augment and control the immune response to as a way of improving the outcome of in several important human diseases. Current research program including:
- To characterise human Tumor specific cytotoxic T cell responses beyond T cell receptor
- To identify the factors determining functional avidity and cancer efficacy of tumor specific cytotoxic T cells in cancer micro-environment
- To study the factors affecting the antigen processing and presentation in cancer cells
- To define the impact of IFTIM3 genetic variation on Influenza, and other virus infection, immune responses and disease outcome
Recent publications
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Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses
Journal article
Barrett JR. et al, (2021), Nature Medicine, 27, 279 - 288
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T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1/2 clinical trial
Journal article
Ewer KJ. et al, (2021), Nature Medicine, 27, 270 - 278
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Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
Journal article
Voysey M. et al, (2021), The Lancet, 397, 99 - 111
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Clinical perspective and practices on pleural effusions in chronic systemic inflammatory diseases.
Journal article
Yao X. et al, (2020), Breathe (Sheffield, England), 16
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Performance characteristics of five immunoassays for SARS-CoV-2: a head-to-head benchmark comparison
Journal article
Ainsworth M. et al, (2020), The Lancet Infectious Diseases, 20, 1390 - 1400