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Address
Wellcome Centre for Human Genetics

Molecular specificity which underlies receptor-mediated cross-species transmission of a pathogenic henipavirus

Structure-based classification of paramyxoviral attachment glycoproteins reflects receptor specificity.

Thomas Bowden

Professor of Structural Biology

Structural biology of antibodies and viral glycoproteins

Glycoproteins feature on the surface of many enveloped viruses, and as such, are attractive targets for therapeutic design. Through the application of techniques in structural biology, immunology, and cell biology, our group aims to harness knowledge of glycoprotein structure and function to inform upon the rational development of therapeutics and preventive medicines. We have a particular interest in the development and characterisation of neutralising and protective monoclonal antibodies and look to apply the insights gleaned from our biophysical studies to identify sites of vulnerability that may be targeted through rational vaccine design.