Research groups
Colleges
William Matlock
BSc (Hons.), MSc, DPhil
Postdoctoral research assistant
- Computational biologist in Modernising Medical Microbiology
- Microbiology Society ECM Board Reviewer
My Research
I am interested how mobile genetic elements, such as plasmids, integrons, and transposons, evolve and spread antimicrobial resistance genes. I spend most of my time developing novel genomic and epidemiological methods to then apply them in clinical settings, but I also work on more fundamental questions surrounding plasmid evolution.
Recent publications
DNA-damaging combination treatments impose genotype-specific constraints on hypermutator evolvability
Preprint
Mulkern AJ. et al, (2026)
Conjugation structures plasmid populations through host-lineage restriction
Preprint
Matlock W. and MacLean RC., (2026)
Plasmid dynamics driving carbapenemase gene dissemination in healthcare environments: a nationwide analysis of closed Enterobacterales genomes.
Journal article
Koh V. et al, (2025), Nature communications, 16
Escherichia coli phylogeny drives co-amoxiclav resistance through variable expression of TEM-1 beta-lactamase
Journal article
Matlock W. et al, (2025), Nature Communications, 16