Associate Professor, Principal Investigator
Structural guided drug discovery of rare diseases
Structural biology at the crossroad of genetic diseases and drug discovery
Wyatt Yue is a structural biologist with an MA (Biochemistry) from University of Oxford, and a PhD (Crystallography) from Birkbeck College, University of London. He specializes in the use of structural, biochemical and chemical biology approaches to study diverse metabolic protein families in the human genome, with the aim of deciphering the molecular mechanism of human inherited diseases at the protein level.
He leads the ‘Metabolism & Organelle Biogenesis (MOB)’ group at the Centre of Medicines Discovery, Nuffield Department of Medicine. His team has to date deposited >200 human crystals structures in the Protein Data Bank (PDB). Through collaborations with clinicians and pharma partners, his team aims to translate basic science into design of small molecule therapeutics for rare diseases with unmet need.
Current areas of focus include: multiprotein complex machines, glycogen synthesis, vitamin B12 metabolism and Leloir pathway of galactose metabolism.
Human aminolevulinate synthase structure reveals a eukaryotic-specific autoinhibitory loop regulating substrate binding and product release.
Bailey HJ. et al, (2020), Nature communications, 11
The natural history of infantile mitochondrial DNA depletion syndrome due to RRM2B deficiency.
Keshavan N. et al, (2019), Genet Med
RAC1 missense mutations cause diverse phenotypes and define Rhopathies as a new group of developmental disorders
Reijnders MRF. et al, (2019), EUROPEAN JOURNAL OF HUMAN GENETICS, 27, 238 - 238
Expanding the genetic and phenotypic spectrum of branched-chain amino acid transferase 2 (BCAT2) deficiency.
Knerr I. et al, (2019), J Inherit Metab Dis
Genetic, structural, and functional analysis of pathogenic variations causing methylmalonyl-CoA epimerase deficiency.
Heuberger K. et al, (2019), Biochim Biophys Acta Mol Basis Dis, 1865, 1265 - 1272