DPhil, M.S., B.S.
3D In Vitro Models;Biomedical Engineering;Physiomimetic systems
Human Physiomimetic Microsystems
Xiao is a Training Fellow sponsored by National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs). Before her DPhil training with Institute of Biomedical Engineering in University of Oxford, Xiao obtained her bachelor’s degree in Pharmaceutical Sciences followed by a master’s degree in Chemical Biology from Peking University in China. Xiao’s expertise is miniaturised human physiomimetic systems, creating artificial tissue to replicate physiological and pathological processes in the human body. Examples include but are not limited to microvasculature architecture, cancer angiogenesis microenvironment and neural stem cell niche. She uses mainly human-originated materials, including cell lines which were genetically modified to be immortal, and primary tissue and cells which reflect individual features. She designs and develops highly interdisciplinary modelling and analysis tools with her collaborators in UK and China, and her current work in TDI focuses on developing and adapting advanced 3D in vitro models for phenotypic screenings, facilitated via techniques such as co-culture, hydrogel engineering, perfused mini-bioreactors and microfluidic organs-on-chips. These models will bridge the current 2D monolayer in vitro models and conventional animal models by mimicking the dynamics of tissue growth, differentiation, phenotypic plasticity and interacellular, cellular-matrix communications in a 3D, heterogeneous perfusion environment. Xiao is also an active member of the US Radiation Research Society, and a reviewer for interdisciplinary engineering journals such as Biotechnology Letters.
Epigallocatechin-3-gallate inhibits the growth of three-dimensional in vitro models of neuroblastoma cell SH-SY5Y
Wan X. et al, (2021), Molecular and Cellular Biochemistry
ReN VM spheroids in matrix: A neural progenitor three-dimensional in vitro model reveals DYRK1A inhibitors as potential regulators of radio-sensitivity
Wan X. et al, (2020), Biochemical and Biophysical Research Communications, 531, 535 - 542
An Improved In Vivo Angiogenesis Model of Chicken Chorioallantoic Membranes in Surrogate Shells Revealed the Pro-angiogenesis Effects of Chylomicrons
Wan X. et al, (2019), Vascular Cell, 11
In vitro cancer models
Wan X. et al, (2019), Comprehensive Biotechnology, 550 - 559
Perfused Three-dimensional Organotypic Culture of Human Cancer Cells for Therapeutic Evaluation
Wan X. et al, (2017), Scientific Reports, 7