The Nuffield Department of Clinical Medicine is part of the Medical Sciences Division. It hosts one of the largest groupings of Biomedical Researchers in the University Sector, and is also responsible for a significant part of the teaching of clinical medical students with the Oxford Medical School.
People continue to die around the world from infections for which there is no vaccine. A better understanding of immunity to a range of infectious diseases could help improve treatments and vaccine design. Dr Susie Dunachie discusses melioidosis, a tropical bacterial infection caused by by Burkholderia pseudomallei, which is often induced by diabetes.
A broad range of common diseases are associated with variants in the genome sequence that regulate the expression of genes involved in the immune system. In the course of investigating how these variants affect a person’s susceptibility to disease, Dr Julian Knight's team of researchers at the Wellcome Trust Centre for Human Genetics has found that stimulating cells involved in fighting infection often provokes genes of interest to reveal themselves.
New research aims to find a cure for HIV by waking up dormant HIV in cells to be able to eradicate the virus from the body. Dr John Frater from Oxford University explains ‘The next chapter [for HIV research] is to try and find a cure for HIV. And this means bringing in a whole new way of thinking about the infection and introducing a whole new range of therapies … What we need to be is very cautious and very steady in what we’re talking about.’
The Structural Genomics Consortium (SGC) Oxford seeks to solve the structures of human proteins of medical relevance and place them into the public domain without restriction. Using these structures and the reagents generated as part of the structure determination process as well as the chemical probes identified, we work with organisations within Oxford, the UK and the rest of the world to further the understanding of the biological roles of these proteins. We have particular interests in human protein kinases, metabolism-associated proteins, integral membrane proteins and proteins associated with epigenetics.
Medical Grand Rounds are the key educational meetings for consultants, juniors and medical students, held every Thursday in Lecture Theatre 1 between 1pm and 2pm down in the John Radcliffe Hospital. Chaired by NDM’s Head of Department, Prof Sir Peter Ratcliffe, presentations revolve around clinical cases and are followed by lively, educational discussion.