Colleges
Ian Tomlinson
Professor of Molecular and Population Genetics
- The identification of genes that predispose to colorectal and other cancers
- Functional genetics of colorectal tumorigenesis, with emphasis on the relative importance of selection and genomic instability.
- Cancer genes and metabolism.
- Cancer evolution.
Recent publications
Germline haploinsufficiency of MUTYH causes mutational signature SBS18 in multiple tumour types and specifically raises colorectal cancer risk.
Journal article
Sherwood K. et al, (2026), NPJ precision oncology
Characterisation of bacteria‐induced colitis and its modulation by probiotics in naked mole rats: a new mammalian model for acute inflammatory disease
Journal article
Hart DW. et al, (2026), The Journal of Pathology, 268, 493 - 511
HLA Heterozygosity Influences Colorectal Cancer Risk and Survival Outcome.
Journal article
Tsai Y-Y. et al, (2026), Gastroenterology, 170, 619 - 622
Large-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer.
Journal article
Billaud A. et al, (2026), Breast (Edinburgh, Scotland), 85
Negative Selection Maintains Grossly Altered but Broadly Stable Karyotypes in Metastatic Colorectal Cancer.
Journal article
Cross WCH. et al, (2026), Cancer discovery, 16, 218 - 234