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Kilian Huber

Contact information


kilian.huber@cmd.ox.ac.uk


ChemBioHub - Huber Lab Website


ORCID ID https://orcid.org/0000-0002-1103-5300


NDM Research Building

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Kilian Huber

Associate Professor

  • Senior Group Leader Chemical Biology & Chemical Probes

Chemical Biology - Drug Discovery - Proteomics - Systems Pharmacology - Medicinal Chemistry

Probing Biology with Small Molecules for Drug Target Discovery

Our group uses chemical biology to uncover new principles of cellular regulation and identify points of intervention for future medicines. By designing small molecules that probe biological systems, we can reveal hidden mechanisms - and ultimately, develop strategies to restore cellular balance in disease.

Chemical biology bridges chemistry and biology to create “chemical probes” that explore how proteins work and assess their potential as drug targets. Candidate targets may emerge from genetic studies linking specific genes to disease, from genome-editing or RNA-interference screens, from phenotypic compound screens, or from existing medicines with unexplained mechanisms.

To identify, explore, and validate new targets, the Huber Laboratory integrates a wide range of discovery approaches - including small-molecule and phenotypic screening, biochemical and structural biology, protein–protein interaction and chemical proteomics, medicinal chemistry, and genetic perturbation methods such as RNAi and CRISPR-based editing.
By combining these complementary techniques, we aim to generate high-quality chemical probes that illuminate fundamental biology and provide starting points for drug discovery.

Recent publications

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