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Understanding the immunity of recovered Covid-19 patients

News

Thousands of lives could be saved by measuring the strength of the antibody response in those who have had the virus and how long their immunity may last for. Professor Paul Klenerman and his team at the University of Oxford have partnered with Oxford University Hospitals NHS Foundation Trust (OUH) to test thousands of healthcare workers.

Simon Leedham appointed as Professor of Molecular and Population Genetics

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Congratulations to Simon Leedham BSc PhD QMUL, MB BS London, FRCP, Professor of Gastroenterology and Wellcome Trust Senior Research Fellow in Clinical Science in the Wellcome Trust Centre for Human Genetics, has been appointed to the Professorship of Molecular and Population Genetics in the Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine. He took up the post on 1 October 2020 and will be a Fellow of Queen's College, Oxford.

Prof Sarah Walker receives OBE

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Prof Walker was recognised for services to academia and the COVID-19 response. Sarah is also the chief investigator and academic lead for the National Covid-19 Infection Survey, a collaboration between the University and the Office for National Statistics (ONS), investigating prevalence and incidence of current and past infections of the virus in the UK.

Comparison of five tests used to detect COVID-19 antibodies shows Siemens and Oxford assays met regulatory targets

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New research shows that, in a head-to-head comparison of five tests used to detect COVID-19 antibodies (known as ‘immunoassays’), an assay manufactured by Siemens and one developed by an academic partnership led by the University of Oxford had the most accurate results. The study is published in The Lancet Infectious Diseases.

Evaluation of LamPORE rapid tests for Covid-19 show high levels of diagnostic sensitivity

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Scientists from the University of Oxford’s Nuffield Department of Medicine have today published their evaluation of LamPORE, a novel diagnostic platform for detecting SARS-CoV-2 RNA. It combines loop-mediated isothermal amplification with nanopore sequencing. This technology has the potential to analyse thousands of samples per day on a single instrument.

Oxford’s OpenABM-Covid19 mathematical model helps to control the coronavirus epidemic

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A team of mathematical modellers and epidemiologists at Oxford University’s Nuffield Department of Medicine release the latest model of a population responding to the coronavirus epidemic. The model - OpenABM-Covid19 - provides public health decision-makers with the ability to review the potential progression and outcome of the coronavirus, including fluctuations in infected individuals, hospitalisations, intensive care unit (ICU) admissions and deaths, and assess the impact of test and trace programmes.

New research shows tracing apps can save lives at all levels of uptake

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The latest research findings from a team of modellers and epidemiologists at Oxford University’s Nuffield Department of Medicine and Google Research suggest digital contact tracing, such as that based on Google and Apple’s Exposure Notification System (ENS), can help to control the epidemic at low levels of app uptake.

Persistent immune memory of COVID-19 found in recovered patient T cells

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Oxford University researchers have found that natural infection with COVID-19 produces a robust T cell response, including inducing T cell ‘memory’ to potentially fight future infections.

Collaboration with Magdalen College outreach to run remote work experience

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Ludwig Oxford's Dr Tammie Bishop organised a week of work experience for fifteen year 12 students in collaboration with the Magdalen Outreach Team. University Research Lecturer Dr Tammie Bishop works in the laboratory led by 2019 Nobel Prize-winning Sir Peter Ratcliffe (Target Discovery Institute & Ludwig Institute for Cancer Research) which conducts research into hypoxia, as well as currently being involved in research into the role of hypoxia in SARS-CoV-2.

Latest version of COVID-19 contact tracing app ready for testing on the Isle of Wight and Newham, London

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The Department of Health & Social Care announced the latest version of the contact tracing app will be tested on the Isle of Wight and with NHS volunteers from this week, and in the London Borough of Newham from next week. The app will enable you to report your symptoms and book a test directly through the app. If you test positive for COVID-19, your close proximity contacts from the last 2 weeks will be notified and advised to isolate to prevent onward spread of the virus.

Dave Stuart awarded The Gabor Medal 2020

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The Royal Society has today announced that it is awarding its Gabor Medal to David Stuart, who is Professor of Structural Biology in the Nuffield Department of Medicine and the Life Sciences Director of the Diamond Light Source, the National Synchrotron at Harwell. Professor Stuart is currently leading a large number of projects relating to the University’s response to COVID19, which include studying the structure of SARS-Cov-2 and a series of anti-viral drug discovery programmes. He is also leading the Oxford research team providing antibody immunity data on the UK population for the Office of National Statistics.

New study reveals Oxford coronavirus vaccine produces strong immune response

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A team of scientists at NDM’s Jenner Institute and The Oxford Vaccine Group has taken the next step towards the discovery of a safe, effective and accessible vaccine against coronavirus. The results of the Phase I/II trial published recently in the scientific journal, The Lancet, indicate no early safety concerns and induces strong immune responses in both parts of the immune system.

Oxford study suggests notable decline in coronavirus cases and R rate on Isle of Wight after launch of the test and trace programme

News

team of epidemiologists, mathematical modellers and economists at NDM's Big Data Institute has released an independent analysis of the trends in the number of coronavirus infections (incidence) on the Isle of Wight, UK before and during the first phase of the test and trace programme (TT), including the first version of the NHS contact tracing app. Results of the study, which has not yet been subject to formal peer review, can be explored on EpiNow interactive tool.

New NDM titles awarded

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Many congratulations to the members of the NDM who have been awarded the title of Associate Professor or University Research Lecturer in this year’s Recognition Of Distinction exercise! The full list of recipients can be found here:

Future of Oxford professorship in vaccinology secured with £3.5 million gift

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A generous gift of £3.5 million from Lakshmi Mittal and his family has secured the future of a critical professorship in vaccinology at the University. The post, which is currently held by NDM's Professor Adrian Hill, will be known as the Lakshmi Mittal and Family Professorship of Vaccinology in recognition of this support.

The Ludwig Institute for Cancer Research welcomes cancer epigenetics researcher Yang Shi

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Yang Shi has been appointed a Member of the Ludwig Institute for Cancer Research to continue his research into chromatin, RNA modifications and cancer. He joins NDM's Ludwig Institute from Harvard University, and is a world leader in the field of epigenetics, which explores how chemical modifications to chromatin—the combination of DNA and histone proteins—control the organisation and expression of the human genome.

The Duke of Cambridge visits Oxford Vaccine Centre

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The Duke of Cambridge visits the University of Oxford’s Oxford Vaccine Centre, to learn more about their work to establish a viable vaccine against COVID-19. The Duke paid a visit to the Oxford Vaccine Centre facility at the Churchill Hospital in Oxford where the vaccine has been developed and trials are now underway. During his visit, The Duke was briefed about the Group’s work by NDM's Professor Sarah Gilbert, Professor of Vaccinology at the Jenner Institute, who developed the vaccine and Professor Andrew Pollard, Professor of Paediatric Infection and Immunity, who is leading the clinical trial team.

Oxford University Coronavirus Research Webinar

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Originally screened live on Friday 22nd May 2020, here is another chance to view the Vice-Chancellor, Professor Louise Richardson, being joined by Professor Richard Cornall, Head of the Nuffield Department of Medicine, to talk about the University's research into the COVID-19 virus.

Chan Zuckerberg Initiative awards funding to Oxford team to support inflammation research

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NDM's Dr Anita Milicic from the Jenner Institute, Old Road Campus Research Buillding and Dr Calliope Dendrou from the Wellcome Centre for Human Genetics, are part of a group with Professor Mark Coles from the Kennedy Institute who have received a share of $14 million in funding from the Chan Zuckerberg Initiative as one of 29 projects that will explore emerging ideas regarding the role of inflammation in disease.

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