News — Nuffield Department of Medicine

Mapping genetic relatedness at a population scale

30 May 2023

McGill University and Big Data Institute researchers have developed a new method to simulate genomes based on a population-scale genealogy dating back to the arrival of the first French settlers in Canada.

Study highlights evidence gap in the quality of antiretrovirals

23 May 2023

A recent study suggests that, although there is sparse evidence, substandard and falsified antiretrovirals occur and enhanced surveillance is needed.

Genetic signals causing ankylosing spondylitis uncovered in a new study

26 April 2023

A study by Nuffield Department of Medicine’s Wellcome Centre for Human Genetics, and collaborating researchers have uncovered the genetic signals that cause ankylosing spondylitis, a type of spinal arthritis.

New study reveals significant clues for targeted therapies for sepsis

24 April 2023

Researchers from NDM’s Wellcome Centre for Human Genetics and the Queen Mary University have found evidence of how the normally protective response of the immune system to infection can go wrong in sepsis, offering exciting possibilities for the development of more targeted therapies for this deadly condition.

Rift Valley fever vaccine trial shows positive results

12 April 2023

Researchers from the Nuffield Department of Medicine’s KEMRI-Wellcome Trust Research Programme and the University of Oxford have recently reported promising results from a phase 1 clinical trial of their ChAdOx1 RVF vaccine against Rift Valley fever in humans.

New global study links pain and genetic basis of endometriosis

14 March 2023

Researchers at NDM’s Wellcome Centre for Human Genetics and Nuffield Department of Women’s & Reproductive Health, in collaboration with 25 teams across the world have found compelling genetic evidence linking endometriosis to other types of pain.

Combination therapy is found to be more effective on severe scrub typhus

2 March 2023

A team from Mahidol Oxford Tropical Medicine Research Unit (MORU) in Bangkok along with Prof Varghese and the INTREST trial investigators in India, finds the combination of antibiotics is significantly more effective than the current monotherapy.

Expectations for polygenic scores need to be realistic

1 March 2023

Testing a population for multiple genes at once will always be limited in its ability to accurately predict disease risk, experts are warning.

MORU study shows ivermectin not effective treatment against COVID

23 February 2023

Researchers at NDM's Mahidol Oxford Tropical Medicine Research Unit found that high doses of the drug ivermectin, controversially recommended by some high-profile political and media figures during the COVID-19 pandemic, are ineffective at treating the COVID-19 virus.

NHS COVID-19 app saved 10,000 lives

22 February 2023

A team of experts at NDM’s Pandemic Sciences Institute and the Department of Statistics at the University of Warwick estimate the NHS COVID-19 app prevented around 1 million cases, 44,000 hospitalisations and 9,600 deaths during its first year.

New research opens new strategies for cancer therapeutics

13 February 2023

Researchers from NDM’s Target Discovery Institute and CAMS Oxford Institute, and the Department of Biochemistry uncovered at the molecular level how protein BIRC6 (a giant ubiquitin ligase) keeps cells alive.

New genetic mutation linked to rare conditions

30 January 2023

Researchers from Wellcome Centre for Human Genetics at the Nuffield Department of Medicine, have discovered that a rare type of genetic variant can be responsible for two well-known skeletal disorders.

Essential research by COI improves understanding of COVID

20 January 2023

Since the start of the pandemic, the CAMS-Oxford Institute (COI) has carried out 11 projects to better understand COVID-19, resulting in 21 published research articles.

Study opens a pathway to better diagnosis and treatment of autoimmune diseases

9 December 2022

A study published in Nature by researchers from Washington University School of Medicine in St. Louis, Stanford University School of Medicine and Oxford University have developed a way to find the crucial protein fragment that drives autoimmunity, as well as the immune cells that respond to it.

Constant genetic surveillance needed to counter multidrug-resistant malaria strains

5 December 2022

Continual monitoring of genetic changes in parasite populations is a powerful tool for analysing malaria outbreaks and identifying emerging multidrug-resistant malaria strains, say researchers from NDM’s Mahidol-Oxford Tropical Medicine Research Unit (MORU).

Lancet study informs WHO guidelines for the treatment of malaria in pregnancy

2 December 2022

The study from the Worldwide Antimalarial Resistance Network (WWARN) provides compelling evidence that artemether-lumefantrine should now replace quinine as the treatment of choice in the first trimester.

Bacterial infections linked to one in eight global deaths, according to GRAM study

22 November 2022

Data showing 7.7 million deaths from 33 bacterial infections can guide measures to strengthen health systems, particularly in low-income settings

New study provides important insights into TB correlates of protection

8 November 2022

Researchers from the Nuffield Department of Medicine’s Jenner Institute have today reported the findings from a study investigating whether previously identified correlates of protection associated with the risk of tuberculosis (TB) disease could also be associated with the risk of infection from the bacteria that causes TB.

Therapeutic HIV vaccine achieves encouraging results

4 November 2022

A phase I/IIa clinical trial that the Nuffield Department of Medicine's Jenner Institute collaborated on has demonstrated that a T-cell therapeutic HIV vaccine was associated with better control of the virus rebound when antiretroviral therapy (ART) was temporarily withdrawn.

Gene associated with better immune response after COVID-19 vaccination identified

17 October 2022

Researchers from the Nuffield Department of Medicine have today reported new findings from a study exploring how certain genes can help generate a strong immune response following vaccination with two commonly used COVID-19 vaccines – identifying a particular gene associated with a high antibody response.

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