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The latest news, updates and announcements from the Nuffield Department of Medicine.

Benefit of blood transfusion in Visceral Leishmaniasis patients unclear

Publications & research news

A new review summarises existing evidence gaps regarding when blood transfusions should be carried out for visceral leishmaniasis patients. The review is published in Transactions of the Royal Society of Tropical Medicine and Hygiene.

Symposium enables NDM early researchers to network and share research

Department

On June 7, 2024, the second annual Jenner Institute Early Researchers Symposium was held at St Anne's College, bringing together a vibrant community of over 80 DPhil Students, Research Assistants, Technicians and Apprentices from across the Nuffield Department of Medicine to network, share their research and discuss career aspirations.

Caesar Atuire appointed International Association of Bioethics President

News

Many congratulations to Dr Caesar Atuire who has been appointed President of the International Association of Bioethics.

Researchers find dramatic acceleration of SARS CoV2 viral clearance rates

Publications & research news

Running continuously since Sept 2021, the PLATCOV trial at NDM's Mahidol Oxford Tropical Medicine Research Unit has randomised over 1700 patients presenting with COVID-19 infections. Work by PLATCOV’s Dr Phrutsamon Wongnak published in the Lancet Infectious Diseases has shown that rates of oropharyngeal viral clearance have accelerated dramatically since the trial started: A SARS CoV2 viral clearance half-life in untreated patients of around 16 hours In Sept 2021 had reduced to around 9 hours by Oct 2023. The results highlight the importance of pharmacometric platform trials like PLATCOV, so that we are prepared for the next pandemic.

Genetic variants causing cryptic diseases identified

Publications & research news

Researchers from NDM’s Centre for Human Genetics have identified types of genetic variants that lead to a range of rare diseases but are not picked up by standard genetic testing.

Pandemic computer simulations to guide future vaccine trials

News

Researchers from the Pandemic Sciences Institute at NDM are launching a new computer simulations project to model vaccine clinical trial designs and strengthen global response to pandemic threats.

Academy of Medical Sciences elects two NDM researchers as new Fellows

Awards Department News

The Academy of Medical Sciences has elected two medical scientists from the Nuffield Department of Medicine to its fellowship in 2024.

Improving pneumonia recovery in malnourished African children

Publications & research news

A project by the KEMRI Wellcome Trust Research Programme at NDM highlighted the importance of future trials focussing on high-risk, undernourished children and using feeds tailored to their metabolic needs.

NDM scientists elected as Royal Society Fellows

Awards Department News

Two academics from the Nuffield Department of Medicine have joined the Royal Society as Fellows.

Nanotechnology enables new version of all-in-one coronavirus vaccine

Publications & research news

CAMS Oxford Institute researchers introduced an improved version of a novel all-in-one vaccine against coronavirus threats.

New study maps the crucial factors in inflammation control

Publications & research news

A Cell Reports study from the Target Discovery Institute and CAMS Oxford Institute provides an intricate time-resolved molecular map of different phases of NLRP3 inflammasome activation and unveils ubiquitin C-terminal hydrolase 1 (UCH-L1) as a modulator of NLRP3 inflammasome assembly and IL-1β production.

Interdisciplinary research provides insights into the genetics of brain asymmetry

Publications & research news

Differences between the left and right sides of the nervous system are seen in all animals, including humans. A study by researchers from University College London and NDM’s Division of Structural Biology reveals a new piece in the puzzle of how such asymmetries can arise.

Prof Yang Shi elected to the US National Academy of Sciences

News

Professor Yang Shi from the Ludwig Institute for Cancer Research at NDM has been elected as a member of the National Academy of Sciences in the United States.

Melanoma research in the Ludwig Institute for Cancer Research

News

For Skin Cancer Awareness Month, the Ludwig Institute for Cancer Research looks at recent research into melanoma from Professors Richard White, Professor of Genetics, and Colin Goding, Professor of Oncology.

New study to improve vaccines and therapeutics development

Publications & research news

A first-of-its-kind study led by the University of Oxford has successfully investigated human immunity against COVID-19 in people who already have antibodies against it.

Unveiling of Medawar Nobel Prize medal

News

The Oxford immunology community celebrated the donation of Sir Peter Medawar’s Nobel Prize medal to the University.

Record number of patients enrolled in a landmark plague trial

News

A randomised controlled trial to evaluate the efficacy and safety of treatments for bubonic plague has enrolled over 220 patients in Madagascar, marking a critical milestone in evidence generation for plague treatments.

Forecasting how best to control and eliminate Neglected Tropical Diseases

Publications & research news

Neglected tropical diseases (NTDs) are a major cause of death, disability, and economic hardship worldwide, particularly in low- and middle-income countries. While many of these diseases are targeted for control, elimination, or eradication by 2030, achieving those targets will be challenging due to disruptions to programmes related to the COVID-19 pandemic and differences in disease transmission across regions, which requires tailoring interventions to local settings.

The potential of the R21/Matrix vaccine to redefine malaria prevention

News

Researchers from the Jenner Institute at NDM will present new exciting data on the R21/Matrix-M malaria vaccine during the 8th Pan-African Malaria Conference, in collaboration with the Rwandan Ministry of Health and the Rwanda Biomedical Centre.

Significant global variation in national COVID-19 treatment guidelines

Publications & research news

A new study, led by researchers at the Infectious Diseases Data Observatory (IDDO) and the Mahidol Oxford Tropical Medicine Research Unit (MORU) at NDM, found that a large number of national guidelines recommend at least one treatment proven not to work.

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