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New combination therapy developed for acute myeloid leukaemia

Researchers in the Shi group at Ludwig Cancer Research Oxford have developed a new combination therapy for acute myeloid leukaemia, showing therapeutic promise by promoting differentiation of immature blood cells.

Study identifies direct link between inflammation and asthma attacks

An international consortium of respiratory scientists, including researchers from NDM’s Experimental Medicine Division, have shed light on the role of inflammation in asthma. Through their findings, they have provided a new way of predicting and preventing asthma attacks.

Up to £16.5 million awarded to global consortium to overcome obstacles in infectious disease research

The International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) has been awarded up to £16.5 million to build on its globally-recognised efforts to prevent illness and deaths from epidemic-prone infectious diseases.

Research team receive £5.5m in funding to transform bowel cancer care

Cancer Research UK and partners have committed £5.5 million in funding to form a world-leading research team, co-led by NDM’s Professor Simon Leedham. The team’s goal is to make personalised medicine a reality for people with bowel cancer.

First human trial of aerosol vaccine delivery launched

The Jenner Institute, in partnership with the Coler Lab at Seattle Children’s Research Institute (SCRI), is set to begin a new clinical trial to test tuberculosis (TB) vaccine safety and the host immune response in a first-in-man aerosol mycobacterial challenge infection model with healthy adult volunteers.

Oxford marks World Tuberculosis Day as vaccine trials continue

Thanks to cutting edge research at NDM's Jenner Institute and Oxford University Clinical Research Unit (OUCRU), Oxford remains at the forefront of research to develop new vaccines to protect against this devastating disease.

Lower-dose yellow fever vaccine as effective as the current standard

In a recent study, researchers at the KEMRI Wellcome Trust Research Programme in Kenya have discovered that a low-dose of the yellow fever vaccine is as effective as the current standard dose.

Prioritising research to better address high-consequence outbreaks

A new paper published in BMC Medicine analyses research prioritisation approaches for high-consequence pathogens.

‘Brain bins’ in neck lymph nodes offer clues about brain health

Scientists have found another clue about how brain health is maintained and how this might be affected by ageing and Alzheimer’s disease, according to a new paper.

New paper outlines ethical issues in clinical metagenomics

Researchers have published the first paper mapping clinical ethics questions raised by new metagenomic techniques for diagnosing disease in clinical practice.

Immune response may be harnessed to control HIV

Researchers have unveiled primary trial results that show encouraging advances in HIV treatment driven by immune-based therapies. New antibody therapies could offer alternative to current treatments.

Melanoma progression driven in part by fatty acid uptake

The Goding lab, working in collaboration with the University Rey Juan Carlos, have shown that fatty acid uptake activates an AXL-CAV1-β-catenin axis to drive melanoma invasiveness.

Study finds previously unidentified genetic determinants of rare disease

A landmark study involving researchers from NDM’s Centre for Human Genetics has identified 69 previously unidentified genetic determinants of rare disease, including uncommon forms of epilepsy and schizophrenia.

Researchers receive funding to develop new therapies for drug-resistant tuberculosis

The Ineos Oxford Institute for antimicrobial research (IOI) has awarded £5 million to a group of interdisciplinary researchers from NDM and other departments at the University, to develop new therapies for drug-resistant tuberculosis.

Bangladesh malaria vaccine and drug administration trial begins

After more than a year of community engagement and preparation in 100 villages with over 12,000 inhabitants across the Chittagong Hill Tracts, a mass malaria vaccine (R21/Matrix M) and drug administration (DHA, piperaquine, and single low dose primaquine) study was launched on 15 February.

Advances in AI can help prepare the world for the next pandemic

In the first study of this kind, NDM’s Pandemic Sciences Institute and Oxford researchers partner with global colleagues to outline how artificial intelligence can transform infectious disease research and save more lives.

Researchers develop AI-powered tools to improve pneumonia care

A team of researchers at OUCRU was recently awarded a multi-million-dollar Discovery Award from the Wellcome Trust to develop AI tools to advance pneumonia research.

At-home test could play key role in type-1 diabetes screening

A new home test to diagnose type-1 diabetes (T1D) is being investigated in a major UK study led by researchers at the National Institute for Health and Care Research (NIHR) Oxford Biomedical Research Centre and NDM's Centre for Human Genetics.

Bowel cancer prediction test for IBD patients 90% accurate

Researchers in NDM have authored a collaborative study which explored a new method for detecting bowel cancer, which was found to be more than 90% accurate at predicting which higher-risk people will develop this type of cancer in the future.

Identifying fake COVID-19 vaccines by analysing vial labels and vaccine liquids

Researchers in the Nuffield Department of Medicine and their collaborators, including the Serum Institute of India, have published an innovative method to identify falsified vaccines without opening the vaccine vial. The new method analyses the vaccine vial label and its adhesive and therefore allows genuine vaccine vials to be retained in the supply chain. This technique can also differentiate genuine Covid-19 vaccine liquid from falsified vaccine surrogates.

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