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‘Single shot’ malaria vaccine could transform global immunisation

Researchers at the Jenner Institute have developed programmable microcapsules to deliver vaccines in stages, potentially eliminating the need for booster shots and increasing immunisation coverage in hard-to-reach communities.

Respiratory syncytial virus vaccine linked to reduced dementia risk

A new study, co-led by researchers at the Centre for Human Genetics, shows that a vaccine against respiratory syncytial virus (RSV) is associated with a 29% reduction in dementia risk in the following 18 months. The findings suggest a novel explanation for how vaccines produce this effect.

Researchers develop AI-assisted tools for dengue care in Vietnam

A team of researchers at the Oxford University Clinical Research Unit in Vietnam are developing AI-based solutions to transform dengue care. These tools include a wearable device and a clinical decision support system.

Study finds potential path to treatment for an aggressive form of leukaemia

In a collaborative new study, researchers at Ludwig Cancer Research Oxford have identified a potential new therapeutic target in blast phase myeloproliferative neoplasm, a particularly aggressive and hard-to-treat form of leukaemia.

Research finds new metabolic clues to survival in tuberculous meningitis

In a collaborative new study led by OUCRU, researchers have found that tryptophan in cerebrospinal fluid is a determinant of lower survival in people with tuberculous meningitis. These findings suggest the possibility that other metabolites could also predict patient outcomes.

Nipah virus vaccine granted European Medicines Agency PRIME designation

Co-led by researchers at the Pandemic Sciences Institute, the Nipah virus has been granted PRIME designation. This recognises the vaccine’s potential to address the unmet medical need arising from the devastating Nipah virus disease, which can be fatal in up to 85% of cases.

Unlocking the potential of genetic data for research and healthcare

Researchers at the Big Data Institute have announced a new data format designed to unlock the potential of the millions of genomes now sequenced in global healthcare systems.

PSI publish first validated tool to measure stigma during disease outbreaks

Researchers at the Pandemic Sciences Institute have published RAPID Stigma Scales to help health professionals monitor stigma in disease outbreak settings, improving outbreak responses globally.

New method reveals access to proteins in ancient human remains

A new method, developed by researchers at the Nuffield Department of Medicine, could soon unlock the vast repository of biological information held in the proteins of ancient soft tissues. The findings, which could open up a new era for palaeobiological discovery, have been published in PLOS ONE.

Project to develop low-cost genome sequencing for pathogens launched

A low-cost genome sequencing technique that was used by thousands of laboratories globally to spot COVID-19 variants will be extended to cover all pathogens, in an ambitious new Wellcome Trust-funded project launched today. The ARTIC-2 project is led by the University of Birmingham and brings together researchers from the Democratic Republic of Congo, Ghana and Kenya with expertise in responding to numerous viral threats using genomic surveillance, including recent outbreaks of Ebola virus and Mpox in Africa.

Molecule enabling new leukaemia treatments discovered

Researchers at the Shi Lab have discovered a first-in-class LSD1 PROTAC degrader, which opens up new therapeutic paths for the treatment of acute myeloid leukaemia. PROTAC degraders are molecules that degrade proteins by using the cell’s own machinery, binding to both the target protein and an E3 ligase, which marks it for degradation by the proteasome.

T cell responses to monkeypox play a part in protecting against infection

A new study, led by researchers at the NDM's CAMS Oxford Institute and the Centre for Human Genetics, TIDU in the MRC Weatherall Institute of Molecular Medicine, the Kennedy Institute and the Dunn School of Pathology, has found that specific T cells could have an impact on the long-term protective responses to future infection.

More effective and affordable treatment strategies for Hepatitis C

NDM's Oxford University Clinical Research Unit (OUCRU) announced promising results from the VIETNARMS trial, a years-long multi-arm clinical trial conducted in Vietnam. The trial found that the readily available and affordable Hepatitis C treatment sofosbuvir/daclatasvir had a >95% cure rate. The results offer important insights into new treatment regimens for Hepatitis C, potentially reducing treatment durations and halving treatment costs.

Coeliac disease may be driven by immune structures in the gut

Researchers in the Nuffield Department of Medicine have found structures of immune cells in the gut that may be driving the response to gluten in people with coeliac disease. These findings could provide a target for future therapies.

New guidelines published for monitoring IBD patients to prevent bowel cancer

Led by NDM’s Professor James East, researchers and clinicians have developed major new guidelines for monitoring patients with inflammatory bowel disease (IBD) to prevent them going on to develop bowel cancer.

Common virus may improve skin cancer treatment outcomes

May is Skin Cancer Awareness Month, and a new study with input from researchers in NDM’s units has revealed that a common virus may positively influence how skin cancer patients respond to current treatments.

New study confirms malaria drug safe for children and reduces disease burden

A major study in The Lancet Infectious Diseases confirms that single low-dose primaquine is safe and effective in reducing malaria transmission in young children. Analysing data from over 6,000 patients, researchers found it effective even in young children and areas with high malaria burden.

Study finds that Treg depletion suppresses tumour growth

A new study, co-lead by Dr Felipe Galvez-Cancino from the Centre for Immuno-Oncology, has shown that Treg cell depletion can suppress tumour growth in one of the deadliest types of cancer.

New combination therapy developed for acute myeloid leukaemia

Researchers in the Shi group at Ludwig Cancer Research Oxford have developed a new combination therapy for acute myeloid leukaemia, showing therapeutic promise by promoting differentiation of immature blood cells.

Study identifies direct link between inflammation and asthma attacks

An international consortium of respiratory scientists, including researchers from NDM’s Experimental Medicine Division, have shed light on the role of inflammation in asthma. Through their findings, they have provided a new way of predicting and preventing asthma attacks.

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