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Search results (163)

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Inhibition of MLLT1 limits growth of MLL-AF4 leukaemias without killing healthy haematopoietic stem cells

Rajhansa S. et al, (2025)

Structure-Guided Design of ISOX-DUAL-Based Degraders Targeting BRD4 and CBP/EP300: A Case of Degrader Collapse.

Edmonds AK. et al, (2025), Journal of medicinal chemistry, 68, 9638 - 9660

Binding-Site Purification of Actives (B-SPA) Enables Efficient Large-Scale Progression of Fragment Hits by Combining Multi-Step Array Synthesis With HT Crystallography.

Grosjean H. et al, (2025), Angewandte Chemie (International ed. in English), 64

Covalent Inhibitors of S100A4 Block the Formation of a Pro-Metastasis Non-Muscle Myosin 2A Complex

Giroud C. et al, (2024), Journal of Medicinal Chemistry, 67, 18943 - 18956

Engineered HMGB1 construct with tandem HMG B domains promotes tissue regeneration without potential for deleterious inflammation or thrombosis

Viñals Guitart Á. et al, (2024)

Enabling equitable and affordable access to novel therapeutics for pandemic preparedness and response via creative intellectual property agreements

Griffen EJ. and Boulet P., (2024), Wellcome Open Research, 9, 374 - 374

Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist

Balıkçı E. et al, (2024), Journal of Medicinal Chemistry, 67, 7245 - 7259

Discovery of a Potent, Selective, and Cell-Active SPIN1 Inhibitor.

Xiong Y. et al, (2024), Journal of medicinal chemistry, 67, 5837 - 5853

Imidazo[1,2-b]pyridazines as inhibitors of DYRK kinases.

Henderson SH. et al, (2024), European journal of medicinal chemistry, 269

Discovery of PFI-6, a small-molecule chemical probe for the YEATS domain of MLLT1 and MLLT3.

Raux B. et al, (2024), Bioorganic & medicinal chemistry letters, 98

Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors

Boby ML. et al, (2023), Science, 382

Turning high-throughput structural biology into predictive inhibitor design

Saar KL. et al, (2023), Proceedings of the National Academy of Sciences, 120

Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors

Schuller M. et al, (2023), Pathogens, 12, 324 - 324

Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4.

Londregan AT. et al, (2023), Journal of medicinal chemistry, 66, 460 - 472

Novel Inhibitors of MLLT1/3, a Critical Component of the Super-Elongation Complex (SEC), Target a Range of Molecularly Defined Acute Leukemias, with a Differential Profile to Menin Inhibition

Pollard J. et al, (2023), BLOOD, 142

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