Kate is a senior scientist (molecular biology) working with the Modernising Medical Microbiology team in the Nuffield Department of Clinical Medicine. Her current research focus is the development of molecular methods exploiting whole genome sequencing for the rapid diagnosis of Mycobacteria infections. She is also investigating the role of antimicrobial resistance in the emergence of clinically important Clostridium difficile strains infecting humans.
Kate completed her PhD in 1995 at Southampton University, determining the first complete genome sequence of a Genogroup II Norovirus. After a few years as a post-doc at Fox Chase Cancer Centre, Philadelphia (USA), she moved to Oxford, joining a team using DNA sequences to study Campylobacter molecular epidemiology. Kate joined the research group at the John Radcliffe Hospital in 2002, where she has continued to use nucleotide sequence data to study the epidemiology and evolution of pathogens including Campylobacter jejuni and C. coli, Clostridium difficile and Norovirus. In parallel with this work, Kate has used her molecular biology background to develop molecular diagnostic assays for pathogens including common respiratory viruses.
DNA Thermo-Protection Facilitates Whole-Genome Sequencing of Mycobacteria Direct from Clinical Samples
George S. et al, (2020), Journal of Clinical Microbiology, 58
Clostridium difficile trehalose metabolism variants are common and not associated with adverse patient outcomes when variably present in the same lineage
Eyre DW. et al, (2019), EBioMedicine, 43, 347 - 355
A Role for Tetracycline Selection in Recent Evolution of Agriculture-Associated
PCR Ribotype 078
Dingle KE. et al, (2019), mBio, 10
Two Distinct Patterns of Clostridium difficile Diversity Across Europe Indicating Contrasting Routes of Spread
Eyre DW. et al, (2018), Clinical Infectious Diseases, 67, 1035 - 1044
A role for tetracycline selection in the evolution of Clostridium difficile PCR-ribotype 078
Dingle KE. et al, (2018)