Dr Katherine Bull is an MRC-Kidney Research UK Professor David Kerr Clinician Scientist, and an Honorary Consultant Nephrologist.
Outline of REsearch
The development of new therapies for kidney disease is hampered by limited understanding of the underlying mechanistic pathways at the cellular level. This contrasts with the situation in cancer biology for example, where detailed understanding of cell biology, including the immune response, is transforming treatment. To make such advances for patients with renal disease, our objective has been to develop a variety of clinical models and tools, and then establish new approaches to interrogate tissue cellular pathology. We apply gene editing, single cell transcriptomics, and renal and immune phenotyping, to models and human samples.
In particular our work focuses on glomerular protein leak, a hallmark of many renal pathologies.
Examples of our work
The effects of Immune complex deposition on glomerular renal cells in lupus nephritis
Autoimmune renal disease such as occurs in Systemic Lupus Erythematosus (SLE) is characterised by the deposition of immune complexes in the renal glomeruli, but little is understood about the cellular responses in the tissue that ultimately lead to renal failure for some patients with SLE. Using inducible models and spatial transcriptomics we are interrogating cellular signals and cross talk in the kidney.
The role of Prolidase in autoimmunity and T cell fateDeficiency in the metalloproteinase prolidase results in a very rare condition with recurrent infections and in some cases autoimmune features including renal immune complex disease. In vivo knock out of the PEPD gene has identified key functions for prolidase in autoimmunity, renal disease and T cell differentiation.
Richard Cornall, University of Oxford
John Todd / Diabetes and Inflammation Laboratory, University of Oxford
Moin Saleem, University of Bristol
Rutger Ploeg / Oxford Transplant Biobank, University of Oxford
Beijing Genomics Institute
Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients
Carr EJ. et al, (2021), The Lancet, 398, 1038 - 1041
Regular RNA screening detects asymptomatic SARS-CoV-2 infection in haemodialysis patients
Storey B. et al, (2021), Nephrology Dialysis Transplantation, 36, 1130 - 1132
An ontogenetic switch drives the positive and negative selection of B cells
Xu X. et al, (2020), Proceedings of the National Academy of Sciences, 117, 3718 - 3727
High-throughput phenotyping reveals expansive genetic and structural underpinnings of immune variation.
Abeler-Dörner L. et al, (2020), Nature immunology, 21, 86 - 100
Systemic silencing of Phd2 causes reversible immune regulatory dysfunction
Yamamoto A. et al, (2019), Journal of Clinical Investigation, 129, 3640 - 3656