Oleg Fedorov
PI, Group Head
- Biochemistry and Biophysics
Molecular Biophysics and Biochemistry group in CMD/TDI Oxford specialises on chemical probe discovery projects, especially in the field of Epigenetics and Ubiquitin system. Main target areas are acetyl-lysine reader domains and E3 ligases. The group supports the wide variety of screening assays developed for most of the targets. The in-depth characterization of drug candidates relies on a series of biophysical techniques established for accurate measurements of thermodynamics of and kinetic parameters of binding. The group also supports and extend the focused libraries of small molecular weight ligands for proteins of interest.
Recent publications
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Fragment Binding to the Nsp3 Macrodomain of SARS-CoV-2 Identified Through Crystallographic Screening and Computational Docking.
Journal article
Schuller M. et al, (2020), bioRxiv
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DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity
Journal article
Schröder M. et al, (2020), Journal of Medicinal Chemistry, 63, 10224 - 10234
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Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1
Journal article
Ni X. et al, (2019), ACS Medicinal Chemistry Letters, 10, 1661 - 1666
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A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function
Journal article
Fagan V. et al, (2019), Journal of Medicinal Chemistry
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Discovery of a potent and selective fragment-like inhibitor of SPIN1
Conference paper
Yan X. et al, (2019), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 258