PI, Group Head
- Biochemistry and Biophysics
Molecular Biophysics and Biochemistry group in SGC/TDI Oxford specialises on chemical probe discovery projects, especially in the field of Epigenetics. Main target areas are currently acetyl-lysine reader domains and histone demethylases. The group supports the wide variety of screening assays developed for most of the targets. The in-depth characterization of chemical probe candidates relies on a series of biophysical techniques established for accurate measurements of thermodynamics of and kinetic parameters of binding. The group also supports and extend the focused libraries of small molecular weight ligands for proteins of interest.
DFG-1 Residue Controls Inhibitor Binding Mode and Affinity, Providing a Basis for Rational Design of Kinase Inhibitor Selectivity
Schröder M. et al, (2020), Journal of Medicinal Chemistry, 63, 10224 - 10234
Structural Insights into Interaction Mechanisms of Alternative Piperazine-urea YEATS Domain Binders in MLLT1
Ni X. et al, (2019), ACS Medicinal Chemistry Letters, 10, 1661 - 1666
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function
Fagan V. et al, (2019), Journal of Medicinal Chemistry
Discovery of a potent and selective fragment-like inhibitor of SPIN1
Yan X. et al, (2019), ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 258
Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1).
Xiong Y. et al, (2019), J Med Chem