Contact information
NDM Research Building, Roosevelt Drive, Oxford OX3 7FZ UK
Paul Brennan
PhD, FRSC
Professor of Medicinal Chemistry
- Director – Centre for Medicines Discovery
- Director of Chemistry – Chemical Probes Portal
My research group works at the interface of chemistry and biology to design probes and inhibitors to investigate the intricate workings of human proteins and cells, with particular interest in epigenetic proteins, small GTPases, and dementia. Research interests include medicinal chemistry, fragment- and structure-based drug design, computational chemistry, organic synthesis, and biochemistry. The group is part of the Alzheimer's Research UK Oxford Drug Discovery Institute (ODDI), and Centre for AI in Precision Medicine at the University of Oxford.
More Information
Recent publications
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The Chemical Probes Portal – 2024: update on this public resource to support best-practice selection and use of small molecules in biomedical research
Sanfelice D. et al, (2024), Nucleic Acids Research
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Targeting APC/C Ubiquitin E3-Ligase Activation with Pyrimidinethylcarbamate Apcin Analogues for the Treatment of Breast Cancer.
Kapanidou M. et al, (2024), Biomolecules, 14
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Covalent Inhibitors of S100A4 Block the Formation of a Pro-Metastasis Non-Muscle Myosin 2A Complex
Giroud C. et al, (2024), Journal of Medicinal Chemistry
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Luminescence-based complementation assay to assess target engagement and cell permeability of glycolate oxidase (HAO1) inhibitors.
Mackinnon SR. et al, (2024), Biochimie
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Structural Dynamics of the Ubiquitin Specific Protease USP30 in Complex with a Cyanopyrrolidine-Containing Covalent Inhibitor
O’Brien DP. et al, (2024)