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Paul Brennan

Paul Brennan


Professor of Medicinal Chemistry

  • Director – Centre for Medicines Discovery
  • Director of Chemistry – Chemical Probes Portal

My research group works at the interface of chemistry and biology to design probes and inhibitors to investigate the intricate workings of human proteins and cells, with particular interest in epigenetic proteins, small GTPases, and dementia. Research interests include medicinal chemistry, fragment- and structure-based drug design, computational chemistry, organic synthesis, and biochemistry. The group is part of the Alzheimer's Research UK Oxford Drug Discovery Institute (ODDI), and Centre for AI in Precision Medicine at the University of Oxford.

Recent publications

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