A team of Oxford University researchers have worked on behalf of UK Biobank to apply sophisticated new statistical techniques to genetic information from all 500,000 volunteer UK Biobank participants. They have ensured high data quality and been able to impute the number of testable genetic variants – the letters in our DNA code that vary from person to person - from 800,000 to 96 million, a more than 100-fold increase in useful data. Imputation compares the selected genotyped DNA with analysis of the full human genome, to allow scientists to accurately predict DNA code at non-selected sections.
Inflammatory Bowel Disease (IBD) is a chronic inflammatory disease with limited treatment options. Up to 40% of patients with IBD fail to respond to conventional therapies, partly due to our limited understanding of the cells that form the large intestine, but also how they change in in patients affected by this disease. The study published today by the group of Professor Alison Simmons at the MRC Human Immunology Unit paves the way for better treatments for IBD by providing the first detailed single cell resolution analysis of colon cells in health and disease.
In a landmark study that may herald a quicker, more tailored treatment for the millions of people around the world living with tuberculosis (TB), UK researchers have shown how our understanding of TB’s genetic code is now so detailed that we can now predict which commonly used anti-TB drugs are best for treating a patient’s infection and which are not.
The Antibiotics and Activity Spaces project is a survey of 4,800 villagers in Thailand and Lao PDR to better understand how people access healthcare and whether there are simple early warning indicators to detect 'problematic' antibiotic use. Marco J Haenssgen and colleagues recently hosted a photography exhibition in Bangkok on rare and vivid narratives of healing in Northern Thailand.
Professor Keith Channon will be replaced as Director of the Oxford BRC by Professor Helen McShane, of the Jenner Institute. Prof McShane said “It is a great honour to have been appointed to lead the Oxford BRC and am very excited about taking up this pivotal role for medical research in Oxford".
The Medical Sciences Divisional Panel has conferred the title of Professor on six members of NDM's academic staff, Associate Professor on ten members of NDM's academic staff and awarded two new University Research Lecturers. They have all been awarded these titles in recognition of their distinction in their respective fields and contributions to the research, teaching and administration of the ...
The American Society of Human Genetics (ASHG) has named Cecilia Lindgren, as the recipient of its 2018 Mentorship Award. This award recognizes ASHG members who have significant records of accomplishment as mentors. It is open to individuals at all academic ranks who have shown a sustained pattern of exemplary mentorship at the graduate student, postdoctoral, residency, or fellowship level.
Congratulations to Professor Mona Bafadhel who as been awarded the prestigious Graham Bull Prize in clinical science and Goulstonian Lectureship from the Royal College of Physicians. This award is made to researchers under the age of 45 for a major contribution to clinical science and as part of the award, Mona will deliver the Goulstonian Lecture which was first endowed in 1635.
Researchers have reported the results of the first randomised clinical trial to test a novel strategy. The approach involves waking up and then killing the ‘sleeping’ HIV that is hiding in the body using an experimental approach known as ‘kick and kill’. Led by Imperial College London, the University of Oxford, MRC Clinical Trials Unit at UCL, and the University of Cambridge, the RIVER study aimed to improve on current care by eradicating HIV from the body, which would represent a major step forward in the search for a cure
The Royal Society Summer Science Exhibition is one of the UK's most prestigious science festivals, offering a packed programme of events and more than twenty exhibits of hands on science and technology. This year scientists from the Department of Biochemistry and the Jenner Institute have collaborated on the 'Designer Malaria Vaccines' exhibit, which explores how structural biology is raising hopes for a vaccine against this killer parasite.
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