A global study to test if either chloroquine or hydroxychloroquine can prevent COVID-19 in vital frontline healthcare workers will open to UK participants at hospital sites in Brighton and Oxford today. Led by the Mahidol Oxford Tropical Medicine Research Unit (MORU) in Bangkok, Thailand, the COPCOV study is a double-blind, randomised, placebo-controlled trial that will enrol 40,000+ frontline healthcare workers and staff from Europe, Africa, Asia and South America who have close contact with patients with COVID-19 to determine definitively if chloroquine and hydroxychloroquine are effective in preventing COVID-19. “COVID-19 is a major risk for frontline healthcare workers around the world,” said COPCOV Co-Principal Investigator Professor Sir Nicholas White
The Randomised Evaluation of COVid-19 thERapY (RECOVERY) Trial has recruited more than 10,000 patients in 176 hospitals in just two months - truly incredible figures for that timescale, making it the fastest ever recruiting individually randomised controlled trial. From conception to launch took just nine days! The trial is being co-led by NDM's Professor Peter Horby and Professor Martin Landray from the Nuffield Department of Population Health (NDPH), and is testing existing drugs, all with well-known side effects and confirmed safety, on hospital inpatients with suspected or confirmed COVID-19.
The Royal Society, the UK’s distinguished academy of science, has announced the election of 62 new Fellows and Foreign Members, which now includes Professor Xin Lu FMedSci FRS
Xin Lu is a cancer biologist distinguished by her contributions to understanding cellular pathways that control cell fate in development and disease, particularly cancer. She has a long-standing interest in how to selectively kill cancer cells, and her major research advances have provided insights into how p53, the most mutated or inactivated tumour suppressor in human cancers, can make life or death decisions for a cell.
NDM's Dr Anita Milicic from the Jenner Institute, Old Road Campus Research Buillding and Dr Calliope Dendrou from the Wellcome Centre for Human Genetics, are part of a group with Professor Mark Coles from the Kennedy Institute who have received a share of $14 million in funding from the Chan Zuckerberg Initiative as one of 29 projects that will explore emerging ideas regarding the role of inflammation in disease. The Chan Zuckerberg Initiative (CZI) was founded by Dr. Priscilla Chan and Mark Zuckerberg in 2015, to leverage technology to help solve some of the world’s toughest challenges. These grants build on CZI’s work in single-cell biology supporting the Human Cell Atlas, a fundamental reference for health and disease.
A team from NDM's Big Data Institute is sharing an epidemiological model to help configure a contact tracing app for coronavirus. The model offers several safe configurations to introduce an app and a framework to optimise the app after it is released. The simulations confirm that if around half the total population use the app, alongside other interventions, it has the potential to stop the epidemic and help to keep countries out of lockdown. These research efforts are supporting several European projects including the UK’s national programme led by NHSX, a joint unit comprised of teams from NHS England and the Department of Health & Social Care.
The world’s largest randomised clinical trial of potential coronavirus treatments is well underway in the UK as part of the race to find a treatment. A number of promising treatments are being tested and, if the science supports it, will be given to NHS patients as quickly as possible. The trial is being coordinated by NDM's Peter Horby, Professor of Emerging Infectious Diseases and Global Health and Martin Landray, Professor of Medicine and Epidemiology at the Nuffield Department of Population Health.
A team of medical researchers and bioethicists at Oxford University has published results today in Science that further our understanding of coronavirus transmission. Professor Christophe Fraser from the Big Data Institute, Nuffield Department of Medicine, a lead author on the Science paper explains, “We need a mobile contact tracing app to urgently support health services to control coronavirus transmission, target interventions and keep people safe".
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