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Our bodies are composed of trillions of cells, each with its own job. To be able to perform these specific jobs, every cell needs a different set of tools, which are formed by the collection of proteins that a cell produces.
James Watson: Data driven definitions of severe malaria
James Watson studies severe malaria in African children, focusing on improving diagnostic accuracy. By analysing clinical data, he aims to distinguish malaria-related severe illness from other infections and estimate true mortality more reliably. His work supports faster diagnosis and treatment, ultimately reducing preventable child deaths in low-resource settings.
Sassy Molyneux: Strengthening health and research systems
Health systems in LMICs face daily stresses such as resource shortages and policy changes, alongside periodic shocks such as epidemics. Enhancing resilience combined with research ethics ensures high-quality research responsive to local communities. Minimising moral distress among frontline staff in international research is crucial for sustaining quality healthcare and advancing science amid challenging conditions.
Jacob McKnight: Preparing Kenya’s health system for extreme weather
In both high- and low-income countries, health systems need to be ready for extreme weather. While sustainability efforts are underway, health systems must cope with events like floods and droughts, which increase healthcare demand and disrupt services. The NEWRISK project in Kenya addresses these challenges, emphasizing resilience and insurance strategies to maintain healthcare access during crises, amid climate change's broad impacts on health systems.
Philippe Guérin: Enabling data reuse to combat infectious diseases
IDDO is a data platform that facilitates the integration and analysis of individual patient data from diverse studies, uncovering new insights otherwise inaccessible. Through meticulous curation and merging of data, IDDO unearth crucial evidence, such as the impact of malaria treatment on malnourished children, a group usually excluded from trials. This comprehensive approach not only informs better treatment strategies but also identifies gaps in current knowledge, guiding future research directions and potentially transforming healthcare guidelines worldwide.
Mike English: Hospitals and Health for All?
Health Systems Collaborative focuses on improving healthcare delivery for low-income populations in Africa, especially in hospitals in rural areas. The AFRHiCARE project, a collaboration with clinicians, social scientists, and economists in Uganda, Kenya, South Africa and Oxford, examines how hospitals can effectively utilise technologies and innovations. We aim to optimise hospital operations to deliver high-quality care, ensuring essential services for patients in resource-poor settings across Africa.
Ben Cooper: Drug-resistant infections and disease dynamics
Infectious diseases carry a huge impact and developing interventions remains a priority. A recent trial in Southeast Asia aimed at shortening antibiotic treatment for ventilator-associated pneumonia, reducing side effects and the risk of antimicrobial resistance. Collaborations underline the global AMR burden and the need for effective solutions, from improved antibiotics use to novel diagnostics and vaccines, crucial amid rising challenges.
Raph Hamers: Infectious diseases research in Indonesia
Infectious diseases research at OUCRU Indonesia addresses prevention, diagnosis and management, focusing on tuberculosis, HIV, COVID-19 and antimicrobial resistance. Participation in the RECOVERY trial contributed to the identification of four treatments for severe COVID-19. Challenges include the need of more research expertise and translating findings into policy. Our goal is to reduce disease burdens through technical and implementation innovations.
Rogier van Doorn: Antimicrobial resistance in Vietnam
OUCRU Hanoi runs a research program on antimicrobial resistance, focusing on the widespread resistance due to antibiotic overuse. Causing over 1.2 million deaths annually, AMR surpasses many major diseases. Our work includes community intervention trials, hospital stewardship programmes and extensive surveillance projects, aiming to inform and implement effective antibiotic use and policies globally.
Abhilasha Karkey: Infectious diseases in Nepal
The primary goal of OUCRU-Nepal is to improve public health in Nepal and South Asia, with focus on typhoid, antimicrobial resistance, and dengue increase linked with climate change. Over the recent years, the TCV typhoid vaccine trial emphasized the importance of regional collaboration and working with policymakers. OUCRU-Nepal has built strong hospital and community relationships, boosting global visibility and collaborations.
Stuart Blacksell: Risk-based approach to biosafety
In biosafety and biosecurity, the recent risk-based approach departs from a rigid one-size-fits-all model. Tailoring safety measures to pathogen and activity levels enhances flexibility, which is vital in resource-limited settings. Systematic reporting of lab incidents globally is lacking, hindering transparency and root cause analysis. Most accidents result from human or procedural errors, highlighting the need for investment in personnel training.
Direk Limmathurotsakul: AMR: local, national, global impact
To fight antimicrobial resistance, researchers at MORU utilise hospital data to assess global impact and guide interventions. By analysing data, they identify hospitals needing support which enables targeted interventions. Automation and simplification aid data utilization in low-middle-income countries. This approach, bridging implementation and epidemiological research, is crucial and has the potential to save many lives.
Naomi Waithira: Data, science and health
MORU Data Management focuses on tropical infectious diseases, gathering data from diverse sources like patient interviews, medical records and laboratory results. This data, stripped of identifying information, is organized for analysis. Past clinical data aids new insights, augmented by mathematical modelling and AI. MORU aims to improve healthcare by leveraging technology for accurate, impactful solutions.